Endocrine Abstracts

Once induction of puberty has been completed the options for sex steroid hormone replacement change to take in to account long term health outcomes and the issues of transition from pediatric to adult care. With regard to the late stages of development, some thought has to be given to the fact that bone mass continues to increase to reach a peak at about the age of 25. It may not be until the age of 18 that meaningful bone density results can be obtained. For those who are slo...

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All women with early onset oestrogen deficiency have an increased risk of cardiovascular disease regardless of aetiology, be it premature ovarian failure, hypopituitarism or Turner Syndrome. The fact that oestrogen deficiency in young women increases CVD risk appears to be in conflict with the adverse effects of oestrogen replacement on cardiovascular morbidity in postmenopausal women. One explanation for this paradox is that oestrogen may slow atherogenesis in young women whi...

It is often said that the transition from paediatric to adult care should be seamless. At the same time, the first visit to an adult clinic is a time to stop, take stock and reorganise. Clinicians must be aware of the importance of this first visit in overcoming the disillusionment that often is felt by an individual as they leave the cosy world of a paediatric service and move into the busy, fragmented world of adult care. However thoroughly a child coming up for transfer is ...

IntroductionWomen with Turner Syndrome (TS), characterised by the complete or partial absence of one X-chromosome in females, are reported to have an increased risk of coeliac disease, inflammatory bowel disease and angiodysplasia. These may contribute to iron deficiency and anaemia through malabsorption or blood loss. This study screened the serum ferritin and haemoglobin measurements in an adult TS population.MethodSerum ferritin concentrations were measured in 1...

Low bone density in women with androgen insensitivity syndrome [AIS] has been attributed to both androgen and oestrogen deficiency. Tall stature in women with AIS has been attributed to the presence of the Y chromosome and to delayed closure of the epiphyses due to relative sex steroid deficiency. In order to gain greater insight into these interactions we have compared bone density and height in four groups of women-27 women with AIS, 15 women with 46XY gonadal dysgenesis, 25...

The requirement for Sestimibi imaging of the parathyroid glands has increased over recent years, partly due to advances in surgical techniques and the need for accurate pre-operative localisation. We audited sestimibi imaging to ensure efficient and appropriate use of this tool in the face of increasing demand. Over two and a half years 128 scans were identified by Nuclear Medicine. We obtained biochemistry and operative status for these using the hospital patient administrati...

Spironolactone (Sp) is an aldosterone-antagonist diuretic, that is traditionally used in the treatment of hirsutism due to its antiandrogenic effects. Sp can inhibit ovarian and adrenal biosynthesis of androgens, compete for the androgen receptor in the hair follicle, and directly inhibit 5alpha-reductase activity. The steroid suppressive effects are so variable that the receptor-blocking action is considered the most important mechanism. It is probable for this reason that co...

Over a third of women with polycystic ovarian syndrome (PCOS) display glucose intolerance and multiple risk factors for cardiovascular disease, including central obesity. Interleukin-6, a cytokine that is mainly derived from adipose tissue, has recently been implicated as an important link in the development of cardiovascular disease in obesity. We determined the relations between circulating Interleukin-6 levels and anthropometric, metabolic and hormonal parameters in 38 wome...

IntroductionWomen with Turner Syndrome have an increased prevalence of hearing loss. Conductive hearing loss (CHL) is thought to be caused by craniofacial abnormalities or defective mucociliary transport resulting in impaired middle ear ventilation, increased otitis media and tympanic perforations. Sensorineural hearing loss (SNHL) progresses with age, possibly due to premature aging. An adult population was assessed for the impact of childhood treatment...